Compositions and Methods for Inducing Nanoparticle-mediated Microvascular Embolization of Tumors
作者： P. Peter Ghoroghchian
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摘要: Nanoparticle mediated microvascular embolization (NME) of tumor tissue may occur after systemic administration PEM, leading to widespread shutdown vascular flow, hemorrhage, and necrosis. PEM constructs are developed that incorporate large amounts iron-containing protein, possess high oxygen affinities, demonstrate delayed nitric oxide binding. Such properties induce selective NME tumors extravasation, will likely enhance the effect VEGFR TKIs and/or mTOR inhibitors.
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