Compositions and methods for delivery of high-affinity oxygen binding agents to tumors

摘要: While tumor hypoxia is recognized as a key barrier to effective chemo and radiation therapy of solid malignancies, an important biological mediator more aggressive phenotype behavior for over 50 years, prior attempts improve oxygenation have relied on increasing the total amount oxygen bound each molecule natural hemoglobin (e.g. through hyperbaric treatments), ease release from (through introduction exogenous allosteric small molecules), or in body by injecting perfluorocarbon emulsions, polymerized pegylated compositions human bovine hemoglobin. The embodiments provide novel approach introducing into vascular system agents that possess inherently higher-affinities molecular hemoglobin, coupling these with inert carriers shield them unwanted interactions within body.