Evolving concepts in the management of lobular neoplasia.

摘要: Lobular neoplasia broadly defines the spectrum of changes within lobule, ranging from atypical lobular hyperplasia (ALH) to carcinoma in situ (LCIS). This continuum lesions is associated with an increased risk for developing subsequent invasive breast cancer, magnitude that corresponding degree proliferative change. The cancer after a diagnosis multicentric, bilateral, and equal both breasts. itself may transform into carcinoma, although frequency this occurrence unknown. Thus, factor be precursor lesion unusual circumstances. management ALH LCIS depends on setting which they are encountered. When diagnosed core needle biopsy, wire localization surgical excision required definitive because rates histologic underestimation approach those ductal (ADH). generally do not require further intervention, even when present at margin. However, bilateral must considered, especially patients have family history cancer. In selected situations, prophylactic mastectomy or without reconstruction considered diagnosed. Although reduces by 90%, represent small subgroup other factors, such as strong evidence genetic predisposition.