SCN11A mRNA levels in female bipolar disorder PBMCs as tentative biomarker for distinct patient sub-phenotypes.

摘要: Bipolar disorder (BD) is a complex neuropsychiatric characterized by recurrent mania and depression episodes requiring lifelong treatment with mood stabilizing drugs. Several lines of evidence, including BD patient iPSC-derived neurons, suggest that neuronal hyperexcitability may underlie the key clinical symptoms BD. Indeed, higher mRNA levels SCN11A, coding for voltage-gated sodium channel NaV 1.9 implicated in nociception, were detected neurons from patients, normalized vitro lithium. Here we studied SCN11A expression peripheral blood mononuclear cells (PBMCs) well-phenotyped female patients controls evaluated their association several sub-phenotypes. We observed PBMCs no records alcohol dependence (p = .0050), psychosis .0097), or suicide attempts .0409). A trend was (FD 1.91; p .052) compared controls. Datamining published postmortem gene datasets indicated dorsolateral prefrontal cortex orbitofrontal tissues Higher phenotype-associated PBMC also ID2 (alcohol dependence, attempts) HDGFRP3 (seasonal pattern). Our findings be associated certain behavioral sub-phenotypes, lack psychosis, among patients. The thus deserves consideration as tentative phenotype modifier