Multicenter validation study of real-time (B-mode) ultrasound, arteriography, and pathologic examination

摘要: The ability of high-resolution ultrasound, angiography, and pathologic examination endarterectomy specimens to identify quantitate atherosclerosis was compared in a five-center study. carotid bifurcation 900 patients evaluated by angiography ultrasound. In 216 cases, high-quality were available for comparison with the preoperative images. All comparisons made blinded fashion. Results indicate that ultrasound is able differentiate angiographically normal from abnormal arteries sensitivity 88% (1077 1233 arteries) accuracy 79% (1251 1578 arteries). Angiographic stenoses equal or greater than 50% diameter accurately identified imaging 72% (1133 this improved addition other functional data (i.e., Doppler spectral analysis oculoplethysmography). There only modest correlation absolute measurements lesion width, minimal lumen, standard lumen two techniques (r = 0.28 0.55). Ultrasound width on average 2 mm those angiography. averaged 1.5 larger when measured techniques. subset which specimens, showed best (mean difference -1.1 mm) correlated -0.1 mm). Neither consistently ulcerated plaques. Although alone has limited usefulness quantitating luminal stenosis, can be use oculoplethysmography. superior quantifying atherosclerotic plaque (lesion width) will an important tool further study lesions.