Functional genomics of human brain development and implications for autism spectrum disorders.
作者： M N Ziats , L P Grosvenor , O M Rennert
DOI: 10.1038/TP.2015.153
关键词:
摘要: Transcription of the inherited DNA sequence into copies messenger RNA is most fundamental process by which genome functions to guide development. Encoded information, epigenetic marks and environmental influences all converge at level mRNA gene expression allow for cell-type-specific, tissue-specific, spatial temporal patterns expression. Thus, transcriptome represents a complex interplay between genomic structure, dynamic experiential demands external signals. This property makes studies uniquely positioned provide insight genetic–epigenetic–environmental processes such as human brain development, disorders with non-Mendelian genetic etiologies autism spectrum disorders. In this review, we describe recent exploring unique functional genomics profile during neurodevelopment. We then highlight two emerging areas research great potential increase our understanding neurogenomics—non-coding interaction networks. Finally, review previous disorder in context, discuss how investigations are beginning identify convergent molecular mechanisms underlying genetically heterogeneous disorder.
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