Randomized clinical trials: is periodontal research good for patients?

摘要: Randomized controlled trials, in which randomization is used to allocate patients a treatment arm, are relatively new concept. trials increasingly high-stakes endeavors requiring high level of planning and considerable financial support. the gold standard by effectiveness various treatments or interventions determined. However, methods involved randomized raise question: clinical research good for participants? This paper discusses patient-centered issues relating example, whether informed-consent process results subjects who knowledgeable informed about their participation, which, turn, involves patient autonomy, health literacy preferences. Other discussed those statistical vs. significance, professional ethics ethical justification differences perceptions between clinicians regarding care being provided trials. Because our goal, as clinicians, provide that improves quality life patient, it would seem logical should include variables rated important valid outcome measures. As researchers, we can no longer afford view from an ivory tower. Research participants, although autonomous agents, inherently different seeking care. Researchers have responsibility consider consent relates subject’s potential therapeutic procedural misperceptions.