Patients’ Preferences in Randomized Clinical Trials

摘要: IN 1976 the National Surgical Adjuvant Project for Breast and Bowel Cancers (NSABP) launched a multicenter randomized clinical trial to compare mastectomy with "lumpectomy," without radiation, in treatment of breast cancer. Two years later, only small fraction expected number patients had been enlisted, was jeopardy because this low rate accrual. What happened? In issue Journal, Taylor her colleagues present results questionnaire study why participating physicians entered so few their eligible into trial.1 They found . . .