Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression
作者： Hong-bin Ji , Gongxian Liao , William A Faubion , Ana C Abadía-Molina , Cristina Cozzo
DOI: 10.4049/JIMMUNOL.172.10.5823
关键词:
摘要: CD4(+)25(+) regulatory T (Treg) cells maintain immunological self-tolerance through mechanisms that are only in part understood. Previous studies suggest the glucocorticoid-induced TNFR-related protein (GITR), which is preferentially expressed on surface of Treg cells, potentially provides a signal abrogates suppression. In this study, we show soluble form mouse GITR ligand (sGITR-L) induces GITR-dependent NF-kappaB activation and blocks vitro suppression mediated by both resting preactivated polyclonal Ag-specific cells. Since sGITR-L along with rIL-2 proliferation it appears can break anergic state Because also up-regulates IL-2 secretion activated CD4(+)25 (-)T these two induced signals synergize to interfere suppressor activity
elsevier.com
highwire.org参考文章(13)
Ethan M. Shevach, CD4+CD25+ suppressor T cells: more questions than answers Nature Reviews Immunology. ,vol. 2, pp. 389- 400 ,(2002) , 10.1038/NRI821
Martha S. Jordan, Alina Boesteanu, Amy J. Reed, Andria L. Petrone, Andrea E. Holenbeck, Melissa A. Lerman, Ali Naji, Andrew J. Caton, Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nature Immunology. ,vol. 2, pp. 301- 306 ,(2001) , 10.1038/86302
Hong-bin Ji, Anita Gupta, Susumu Okamoto, Michael D. Blum, Lujian Tan, Mary B. Goldring, Elizabeth Lacy, Ananda L. Roy, Cox Terhorst, T Cell-specific Expression of the MurineCD3δ Promoter Journal of Biological Chemistry. ,vol. 277, pp. 47898- 47906 ,(2002) , 10.1074/JBC.M201025200
Ethan M Shevach, Mary Collins, Michael C Byrne, Rebecca S McHugh, Matthew J Whitters, Ciriaco A Piccirillo, Deborah A Young, CD4+CD25+ Immunoregulatory T Cells: Gene Expression Analysis Reveals a Functional Role for the Glucocorticoid-Induced TNF Receptor Immunity. ,vol. 16, pp. 311- 323 ,(2002) , 10.1016/S1074-7613(02)00280-7
Byungsuk Kwon, Kang-Yeol Yu, Jian Ni, Guo-Liang Yu, Ihn-Kyung Jang, Young-June Kim, Lily Xing, Ding Liu, Shu-Xia Wang, Byoung S. Kwon, Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand Journal of Biological Chemistry. ,vol. 274, pp. 6056- 6061 ,(1999) , 10.1074/JBC.274.10.6056
Chandrashekhar Pasare, Ruslan Medzhitov, Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells Science. ,vol. 299, pp. 1033- 1036 ,(2003) , 10.1126/SCIENCE.1078231
Shohei Hori, Takashi Nomura, Shimon Sakaguchi, Control of Regulatory T Cell Development by the Transcription Factor Foxp3 Science. ,vol. 299, pp. 1057- 1061 ,(2003) , 10.1126/SCIENCE.1079490
Ethan M. Shevach, Rebecca S. McHugh, Ciriaco A. Piccirillo, Angela M. Thornton, Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunological Reviews. ,vol. 182, pp. 58- 67 ,(2001) , 10.1034/J.1600-065X.2001.1820104.X
Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi, Yasumasa Ishida, Shimon Sakaguchi, Stimulation of CD25 + CD4 + regulatory T cells through GITR breaks immunological self-tolerance Nature Immunology. ,vol. 3, pp. 135- 142 ,(2002) , 10.1038/NI759
Shimon Sakaguchi, Noriko Sakaguchi, Jun Shimizu, Sayuri Yamazaki, Toshiko Sakihama, Misako Itoh, Yuhshi Kuniyasu, Takashi Nomura, Masaaki Toda, Takeshi Takahashi, Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunological Reviews. ,vol. 182, pp. 18- 32 ,(2001) , 10.1034/J.1600-065X.2001.1820102.X