Plasticity of Regulatory T Cells: Subversion of Suppressive Function and Conversion to Enhancement of Lung Allergic Responses

摘要: Activation of CD4+CD25+Foxp3+ naturally occurring regulatory T cells (nTregs) resulting in suppression lung allergic responses requires interaction MHC class I on nTregs and CD8. In the absence CD8 (CD8−/− recipients), transferred restored airway hyperresponsiveness, eosinophilic inflammation, IL-13 levels following allergen exposure. Enhancement was accompanied by reduced expression Foxp3 increased nTregs. CD8−/− recipients pretreated with glucocorticoid-induced TNFR-related protein-ligand Ab, maintained high did not result altered responses. Thus, function can be subverted reducing signaling through protein are converted into IL-13-producing CD4+ mediating