An investigation of relationships between hypoxia-inducible factor-1α gene polymorphisms and ovarian, cervical and endometrial cancers

摘要: Abstract Background DNA sequence variations in HIF-1α gene might yield changes both the production outcomes and activities of gene. Overexpression subunit, resulting from intratumoral hypoxia genetic alterations, has been demonstrated common human cancers is correlated with tumor angiogenesis patient mortality. In this study, we aimed to determine how three single nucleotide polymorphisms (SNPs, C1772T G1790A exon 12, C111A 2) coding regions affect ovarian, cervical endometrial cancer patients Turkish population. A study on relationship not conducted date. Method 102 gynecologic 107 healthy controls were studied. Genotypes analyzed by PCR-RFLP. Results There was no significant difference between ovarian terms distribution genotypes alleles ( P >0.05). However, there a highly increase frequency CT 1772 TT compared controls. fact, 1772T allele-carriers (CT+TT genotypes) showed an association risk wild type (OR=3.84, 95% CI: 1.65–8.93; OR=7.41, 2.33–23.59, respectively). polymorphism associated family history concerning and/or other types, stages (I–IV) grades tumor, smoking habits existence diseases that generate hypoxic microenvironment even after multivariable logistic regression analysis. As for genotypes, frequencies G 98% 100% control group. We found genotype allele subjects. GA AA among patients. polymorphism, did find CA variants or any types Conclusion Our results suggest may be cancers.