Automatic detection of cirrhosis in hospitalized patients: a pragmatic experience.

摘要: BACKGROUND/AIM We evaluated the relevance of a systematic automatic detection cirrhosis using biochemical markers in hospitalized patients. METHODS automatically calculated three free tests (APRI, Fib-4, and Forns) patients consecutively our university hospital between July September, 2010. Patients >18 years not known to suffer from chronic liver disease, were contacted undergo stiffness measurement (LSM) as reference diagnostic tool. To limit false positives, we required at least one APRI≥2 (indicating cirrhosis) Fib-4>3.25 and/or Forns>6.9, without obvious overestimation. RESULTS A total 10,035 APRI, 9903 1250 Forns available 4074 The fibrosis independently influenced by location patient, especially Cardiology (Lower Hematology/Oncology Departments (higher Forns). Overall, 101 (2.48%) suspected have cirrhosis. LSM identified two cases (LSM>13 kPa). In intent-to-diagnose analyses, highest positive predictive values for diagnosis 1.98, 11.76%, respectively. value never exceeded 50% per-protocol analyses when considering with numerous results tests. CONCLUSION patients, on basis was inefficient because too many false-positive results.