High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients
作者： Mariantonia Logozzi , Angelo De Milito , Luana Lugini , Martina Borghi , Luana Calabrò
DOI: 10.1371/JOURNAL.PONE.0005219
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摘要: Background Metastatic melanoma is an untreatable cancer lacking reliable and non-invasive markers of disease progression. Exosomes are small vesicles secreted by normal as well as tumor cells. Human tumor-derived exosomes are involved in malignant progression and we evaluated the presence of exosomes in plasma of melanoma patients as a potential tool for cancer screening and follow-up. Methodology/Principal Findings We designed an in-house sandwich ELISA (Exotest) to capture and quantify exosomes in …
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