Time-specific controlled release dosage formulations and method of preparing same

摘要: The present invention provides a method of achieving the time-specific delivery pharmaceutically active agent to patient in need therapeutic effects agent. includes administering pharmaceutical formulation comprising (a) core including be delivered, and (b) swellable polymeric coating layer substantially surrounding core. delays release from for predetermined period time dependent upon thickness layer. is provided by new which alternately (I) wetting with binder solution, (ii) powdered particles sufficient number times produce dosage having desired