Age of blood and recipient factors determine the severity of transfusion-related acute lung injury (TRALI).

摘要: Critical care patients frequently receive blood transfusions. Some reports show an association between aged or stored and increased morbidity mortality, including the development of transfusion-related acute lung injury (TRALI). However, existence conflicting data endorses need for research to either reject this association, confirm it elucidate underlying mechanisms. Twenty-eight sheep were randomised into two groups, receiving saline lipopolysaccharide (LPS). Sheep further also transfusion pooled heat-inactivated supernatant from fresh (Day 1) 42) non-leucoreduced human packed red cells (PRBC) infusion saline. TRALI was defined by hypoxaemia during within hours histological evidence pulmonary oedema. Regression modelling compared physiology a previous study, using platelet concentrates (PLT). Samples transfused products underwent cytokine array biochemical analyses, their neutrophil priming ability measured in vitro. did not develop that first received saline-infusion. In contrast, 80% LPS-infusion developed following with "stored PRBC." The decreased mean arterial pressure cardiac output as well central venous body temperature more severe induced PRBC" than PLT." Storage-related accumulation several factors demonstrated both PLT", associated vitro priming. Concentrations higher PLT," however, there no difference vivo ovine model, recipient product contributed TRALI. Sick (LPS infused) rather healthy (saline predominantly when but PRBC. "Stored PLT" had different storage lesion profile, suggesting these outcomes may be unique each type. Therefore, PRBC minimise risk