摘要: Abstract HMG CoA reductase inhibitiors (statins) have been shown to be effective lipid lowering agents and are beneficial in the primary secondary prevention of coronary heart disease. However, overall benefits observed with statins appear greater than what might expected from changes levels alone positive effects only partially reproduced other drugs, suggesting addition cholesterol lowering. In experimental models, many cholesterol-independent mediated by inhibition isoprenoids, which serve as attachments for intracellular signalling molecules such small Rho guanosine triphosphate-binding proteins, whose membrane localization function dependent on isoprenylation. This review summarizes endothelial oxidative stress.
springer.com
sci-hub.se 参考文章(80)
VICTOR W. RODWELL, JEFFREY L. NORDSTROM, JONATHAN J. MITSCHELEN, Regulation of HMG-CoA Reductase Advances in lipid research. ,vol. 14, pp. 1- 74 ,(1976) , 10.1016/B978-0-12-024914-5.50008-5
J.K. Liao, Inhibition of Gi proteins by low density lipoprotein attenuates bradykinin-stimulated release of endothelial-derived nitric oxide. Journal of Biological Chemistry. ,vol. 269, pp. 12987- 12992 ,(1994) , 10.1016/S0021-9258(18)99973-4
Yasuko Kureishi, Zhengyu Luo, Ichiro Shiojima, Ann Bialik, David Fulton, David J. Lefer, William C. Sessa, Kenneth Walsh, The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nature Medicine. ,vol. 6, pp. 1004- 1010 ,(2000) , 10.1038/79510
Sepideh Amin-Hanjani, Nancy E. Stagliano, Masaru Yamada, Paul L. Huang, James K. Liao, Michael A. Moskowitz, Mevastatin, an HMG-CoA Reductase Inhibitor, Reduces Stroke Damage and Upregulates Endothelial Nitric Oxide Synthase in Mice Stroke. ,vol. 32, pp. 980- 986 ,(2001) , 10.1161/01.STR.32.4.980
Ulrich Laufs, Beyond lipid-lowering: effects of statins on endothelial nitric oxide. European Journal of Clinical Pharmacology. ,vol. 58, pp. 719- 731 ,(2003) , 10.1007/S00228-002-0556-0
David Fulton, Jean-Philippe Gratton, Timothy J. McCabe, Jason Fontana, Yasushi Fujio, Kenneth Walsh, Thomas F. Franke, Andreas Papapetropoulos, William C. Sessa, Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. ,vol. 399, pp. 597- 601 ,(1999) , 10.1038/21218
Sven Wassmann, Ulrich Laufs, Anselm T. Bäumer, Kirsten Müller, Christian Konkol, Heinrich Sauer, Michael Böhm, Georg Nickenig, Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase. Molecular Pharmacology. ,vol. 59, pp. 646- 654 ,(2001) , 10.1124/MOL.59.3.646
Ulrich Laufs, Diego Marra, Koichi Node, James K. Liao, 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). Journal of Biological Chemistry. ,vol. 274, pp. 21926- 21931 ,(1999) , 10.1074/JBC.274.31.21926
Christoph Maack, Tanja Kartes, Heiko Kilter, Hans-Joachim Schäfers, Georg Nickenig, Michael Böhm, Ulrich Laufs, Oxygen Free Radical Release in Human Failing Myocardium Is Associated With Increased Activity of Rac1-GTPase and Represents a Target for Statin Treatment Circulation. ,vol. 108, pp. 1567- 1574 ,(2003) , 10.1161/01.CIR.0000091084.46500.BB
Nicolas Tapon, Alan Hall, Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton Current Opinion in Cell Biology. ,vol. 9, pp. 86- 92 ,(1997) , 10.1016/S0955-0674(97)80156-1