摘要: The prediction of metabolism-dependent toxicity is a cutting-edge topic in toxicology (Bolt and Hengstler, 2008). shape dose-response curves toxic profiles are strongly dependent on activating or detoxifying metabolism. Most xenobiotic metabolizing enzymes include large numbers isoenzymes with distinct substrate specificities. This diversity started to evolve 200 400 million years ago when reptiles amphibians moved from sea land began eat plants. resulting co-evolution led the establishment phytotoxins which gave plants protection against herbivores, herbivores responded new enzymes. A highlight our partner journal initiation series review articles discussing nomenclature isoenzyme families, genetic organization, polymorphisms, specificities, clinical relevance role carcinogenesis (Mates et al., 2008; Florl Schulz, Strassburg Beyersmann Hartwig, Pelkonen Verstraeten Adam Laufs, To give readers an overview we summarize key messages drug metabolism (Table 1A) enzyme induction 1B).
excli.de
tu-dortmund.de 
sci-hub.st 参考文章(22)
Chen-Ping Chou, Shui-Yuan Lu, Tzuu-Huei Ueng, Modulation of serum concentrations and hepatic metabolism of 17β-estradiol and testosterone by amitraz in rats Archives of Toxicology. ,vol. 82, pp. 729- 737 ,(2008) , 10.1007/S00204-008-0288-8
Christian P. Strassburg, Tim O. Lankisch, Michael P. Manns, Ursula Ehmer, Family 1 uridine-5'-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability. Archives of Toxicology. ,vol. 82, pp. 415- 433 ,(2008) , 10.1007/S00204-008-0314-X
Detmar Beyersmann, Andrea Hartwig, Carcinogenic metal compounds : recent insight into molecular and cellular mechanisms Archives of Toxicology. ,vol. 82, pp. 493- 512 ,(2008) , 10.1007/S00204-008-0313-Y
Tim O. Lankisch, Tracey C. Gillman, Thomas J. Erichsen, Ursula Ehmer, Sandra Kalthoff, Nicole Freiberg, Peter A. Munzel, Michael P. Manns, Christian P. Strassburg, Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene. Archives of Toxicology. ,vol. 82, pp. 573- 582 ,(2008) , 10.1007/S00204-008-0347-1
Andrea R. Florl, Wolfgang A. Schulz, Chromosomal instability in bladder cancer Archives of Toxicology. ,vol. 82, pp. 173- 182 ,(2008) , 10.1007/S00204-008-0280-3
Ruey-Hong Wong, Chiung-Wen Hu, Ching-Ying Yeh, Mu-Rong Chao, Chin-Chun Chen, Jun-Huang Huang, Shih-Hsien Chang, Shin-I Lee, Hong-Shen Lee, Sulfotransferase 1A1 and glutathione S-transferase P1 genetic polymorphisms modulate the levels of urinary 8-hydroxy-2'-deoxyguanosine in betel quid chewers. Archives of Toxicology. ,vol. 82, pp. 313- 321 ,(2008) , 10.1007/S00204-007-0248-8
Oliver Adam, Ulrich Laufs, Antioxidative effects of statins Archives of Toxicology. ,vol. 82, pp. 885- 892 ,(2008) , 10.1007/S00204-008-0344-4
Daya Shankar Srivastava, Anil Mandhani, Rama Devi Mittal, Genetic polymorphisms of cytochrome P450 CYP1A1 (*2A) and microsomal epoxide hydrolase gene, interactions with tobacco-users, and susceptibility to bladder cancer : a study from North India Archives of Toxicology. ,vol. 82, pp. 633- 639 ,(2008) , 10.1007/S00204-007-0276-4
José M. Matés, Juan A. Segura, Francisco J. Alonso, Javier Márquez, Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Archives of Toxicology. ,vol. 82, pp. 273- 299 ,(2008) , 10.1007/S00204-008-0304-Z
Alexandra Borza, Sabine Plöttner, Alexander Wolf, Claudia Behm, Silvia Selinski, Jan G. Hengstler, Peter H. Roos, Hermann M. Bolt, Jürgen Kuhlmann, Wolfram Föllmann, Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes. Archives of Toxicology. ,vol. 82, pp. 973- 980 ,(2008) , 10.1007/S00204-008-0381-Z