Excretion and toxicity of gold-iron nanoparticles.

摘要: Abstract Though gold nanoparticles have been considered bio-inert, recent studies questioned their safety. To reduce the potential for toxicity, we developed a nanoclustering of and iron oxide as nanoparticle (nanorose) which biodegrades into subunits to facilitate rapid excretion. In this present study, demonstrate acid macrophage lysosomal degradation nanorose via loss near-infrared optical shift, clearance in vivo following i.v. administration C57BL/6 mice by showing concentration is significantly reduced 11 murine tissues little 31days ( P From Clinical Editor The toxicity nanomaterials critically important limiting factor more widespread clinical application. Gold classically but authors study clustering (nanorose), excretion, resulting toxicity.