Factors affecting the reliability of behavioral assessments for rodent osteoarthritis models.

摘要: The translational value of osteoarthritis (OA) models is often debated because numerous studies have shown that animal frequently fail to predict the efficacy therapies in humans. In part, this failing may be due paucity preclinical include behavioral assessments their metrics. Behavioral OA can provide valuable data on pain and disability associated with disease-sequelae significant clinical relevance. Clinical definitions for therapeutics center palliative effects. Thus, widespread inclusion behaviors indicative contribute greater success identifying clinically relevant interventions. Unfortunately, assays still encounter pitfalls assay selection, protocol consistency, data/methods transparency. Targeted selection assays, consideration array phenotypes limitations individual necessary identify outcomes appropriately. Furthermore, facilitate accurate comparisons across research groups studies, it improve transparency methods. Finally, establishing agreed-upon clear will reduce convolution both within between studies. Improvement these areas critical continued benefit as translationally research. As such, review highlights current state analyses models.