p53 Polymorphism and Human Papillomavirus Infection in Hong Kong Women with Cervical Cancer
作者： Y.F. Wong , T.K.H. Chung , T.H. Cheung , T. Nobori , G.M. Hampton
DOI: 10.1159/000010282
关键词:
摘要: In this study we investigated the involvement of p53 polymorphism at codon 72, infection and typing human papillomavirus (HPV) correlation with HPV type other clinicopathologic characteristics in 72 Hong Kong women cervical cancer. We developed a simple nonradioactive method for determining gene. The homozygous arginine allele (Arg/Arg) was detected 22 (31%), proline (Pro/Pro) 14 (19%) heterozygous (Arg/Pro) 36 (50%) cases, respectively. Using consensus primers MY11 MY09, 55 (76%) cases. prevalent types were HPV-16 (55%), HPV-18 (16%) HPV-58 (9%). number HPV-positive cases Arg/Arg, Pro/Pro Arg/Pro 17 12 (22%) 26 (47%), not significantly correlated any (p > 0.05). No striking overrepresentation arginine-72 observed HPV-associated results did show that polymorphic form has prognostic significance
karger.com
sci-hub.se 参考文章(15)
Åslaug Helland, Anita Langerød, Hilde Johnsen, Anne O. Olsen, Eva Skovlund, Anne-Lise Børresen-Dale, p53 polymorphism and risk of cervical cancer. Nature. ,vol. 396, pp. 530- 532 ,(1998) , 10.1038/25034
Allan Hildesheim, Mark Schiffman, Louise A. Brinton, Joseph F. Fraumeni, Rolando Herrero, M. Concepcion Bratti, Peter Schwartz, Rodrigue Mortel, Willard Barnes, Mitchell Greenberg, Larry McGowan, David R. Scott, Maureen Martin, Jesus E. Herrera, Mary Carrington, p53 polymorphism and risk of cervical cancer Nature. ,vol. 396, pp. 531- 532 ,(1998) , 10.1038/25040
Agnetha M. Josefsson, Patrik K. E. Magnusson, Nathalie Ylitalo, Pernilla Quarforth-Tubbin, Jan Pontén, Hans Olov Adami, Ulf B. Gyllensten, p53 polymorphism and risk of cervical cancer Nature. ,vol. 396, pp. 531- 531 ,(1998) , 10.1038/25037
Hiroyuki Yoshikawa, Yuji Taketani, Mieko Matsushima, Yasunobu Kanamori, Yusuke Nakamura, Takeo Minaguchi, No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with human papillomavirus 16/18 infection. Cancer Research. ,vol. 58, pp. 4585- 4586 ,(1998)
Alan Storey, Miranda Thomas, Ann Kalita, Catherine Harwood, Daniela Gardiol, Fiamma Mantovani, Judith Breuer, Irene M. Leigh, Greg Matlashewski, Lawrence Banks, Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature. ,vol. 393, pp. 229- 234 ,(1998) , 10.1038/30400
H Y Ngan, S W Tsao, S S Liu, M Stanley, Abnormal expression and mutation of p53 in cervical cancer--a study at protein, RNA and DNA levels. Sexually Transmitted Infections. ,vol. 73, pp. 54- 58 ,(1997) , 10.1136/STI.73.1.54
Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse, Arnold J. Levine, Peter M. Howley, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 Cell. ,vol. 63, pp. 1129- 1136 ,(1990) , 10.1016/0092-8674(90)90409-8
Harald Zur Hausen, Papillomaviruses in human cancers Molecular Carcinogenesis. ,vol. 1, pp. 147- 150 ,(1988) , 10.1002/MC.2940010302
Harald zur Hausen, Papillomavirus infections — a major cause of human cancers Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. ,vol. 1288, pp. F55- F78 ,(1996) , 10.1016/0304-419X(96)00020-0
Alan Storey, Miranda Thomas, Ann Kalita, Catherine Harwood, Daniela Gardiol, Fiamma Mantovani, Judith Breuer, Irene M Leigh, Greg Matlashewski, Lawrence Banks, None, p53 polymorphism and risk of cervical cancer The Lancet. ,vol. 352, pp. 1631- ,(1998) , 10.1016/S0140-6736(05)61083-5