Nucleation theory with delayed interactions: an application to the early stages of the receptor-mediated adhesion/fusion kinetics of lipid vesicles.

摘要: A semiquantitative theory aimed to describe the adhesion kinetics between soft objects, such as living cells or vesicles, has been developed. When rigid bodies are considered, is successfully described by classical Derjaguin, Landau, Verwey, and Overbeek (DLVO) picture, where energy profile of two approaching given a asymmetrical potential wells separated barrier. The transition probability from long-distance short-distance minimum defines rate. Conversely, might follow different pathway reach minimum: thermally excited fluctuations give rise local protrusions connecting bodies. These transient sites stabilized short-range forces (e.g., ligand-receptor interactions membranes brought at contact distance), while they destabilized both repulsive elastic deformation energy. Above critical area site, adh...