Toxicological evaluation of karaya gum; acute and subacute oral toxicity in rats

摘要: Male and female albino rats (Wistar strain) were given single multiple doses of karaya gum suspended either in peanut oil or mixed with basal diet at different concentrations ranging from 0·5 to 8 g gum/kg body weight. The plant did not elicit any overt signs toxicity death both sexes rats. Daily administration dose levels (0, 5, 20 40 diet) for a period 90 days showed no adverse effects male weight, growth pattern, food water intake comparable those the normal There significant biochemical, morphological alterations vital organs experimental animals.