Gonadectomy attenuates turning behavior produced by electrical stimulation of the nigrostriatal dopamine system in female but not male rats.
作者： Terry E. Robinson , Dianne M. Camp , Jill B. Becker
DOI: 10.1016/0304-3940(81)90041-0
关键词:
摘要: Rotational behavior induced by electrical stimulation of ascending dopamine neurons is used as a behavioral model to investigate gender and hormonal influences on extra-hypothalamic systems. Steroid hormones influence the metabolism many dopaminergic drugs, therefore this approach avoids complications inherent in drug-induced models activity. We found that gonadectomy female, but not male, rats severely attenuates stimulation-induced rotational behavior. This suggests some female gonadal steroid hormone(s) may modulate activity neurons, while male do not.
core.ac.uk
sci-hub.se 参考文章(25)
J. F. Mislow, A. J. Friedhoff, A Comparison of Chlorpromazine-Induced Extrapyramidal Syndrome in Male and Female Rats Springer, Boston, MA. pp. 315- 326 ,(1973) , 10.1007/978-1-4684-2007-4_34
A. H. Conney, PHARMACOLOGICAL IMPLICATIONS OF MICROSOMAL ENZYME INDUCTION Pharmacological Reviews. ,vol. 19, pp. 317- 366 ,(1967)
Gordon W. Arbuthnott, Timothy J. Crow, Kjell Fuxe, Lars Olson, Urban Ungerstedt, Depletion of catecholaminesin vivo induced by electrical stimulation of central monoamine pathways Brain Research. ,vol. 24, pp. 471- 483 ,(1970) , 10.1016/0006-8993(70)90186-1
W.C. Koller, W.J. Weiner, H.L. Klawans, P.A. Nausieda, Influence of female sex hormones on neuroleptic-induced behavioral supersensitivity Neuropharmacology. ,vol. 19, pp. 387- 391 ,(1980) , 10.1016/0028-3908(80)90191-4
S. R. Naik, M. R. Kelkar, U. K. Sheth, Attenuation of stereotyped behaviour by sex steroids Psychopharmacology. ,vol. 57, pp. 211- 214 ,(1978) , 10.1007/BF00426890
R. Hruska, E. Silbergeld, Increased dopamine receptor sensitivity after estrogen treatment using the rat rotation model Science. ,vol. 208, pp. 1466- 1468 ,(1980) , 10.1126/SCIENCE.7189902
Louis A. Chiodo, Anthony R. Caggiula, Charles F. Saller, Estrogen increases both spiperone-induced catalepsy and brain levels of [3H]spiperone in the rat Brain Research. ,vol. 172, pp. 360- 366 ,(1979) , 10.1016/0006-8993(79)90547-X
William W. Beatty, Gerald A. Holzer, Sex differences in stereotyped behavior in the rat Pharmacology, Biochemistry and Behavior. ,vol. 9, pp. 777- 783 ,(1978) , 10.1016/0091-3057(78)90356-8
B. J. Winer, Statistical Principles in Experimental Design ,(1962)
Paul M. Bronstein, Stephen M. Hirsch, Reactivity in the rat: Ovariectomy fails to affect open-field behaviors Bulletin of the Psychonomic Society. ,vol. 3, pp. 257- 260 ,(1974) , 10.3758/BF03333460