Genetic and Biochemical Alterations in Non-Small Cell Lung Cancer

摘要: Despite significant advances in the detection and treatment of lung cancer, it causes highest number cancer-related mortality. Recent genetic alterations patient samples along with physiologically relevant animal models has yielded a new understanding molecular etiology cancer. This facilitated development potent specific targeted therapies, based on biochemical present tumor, especially non-small-cell cancer (NSCLC). It is now clear that heterogeneous cell signaling pathways are disrupted to promote NSCLC, including mutations critical growth regulatory proteins (K-Ras, EGFR, B-RAF, MEK-1, HER2, MET, EML-4-ALK, KIF5B-RET, NKX2.1) inactivation inhibitory (TP53, PTEN, p16, LKB-1). How these differ between smokers non-smokers also important for clinical strategies therapies. paper describes targets biological significance each mutation their potential act as therapeutic target.