Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation.

作者: Ian A. Bettencourt , Jonathan D. Powell

DOI: 10.4049/JIMMUNOL.1601318

关键词:

摘要: Immune cell activation and differentiation occurs concurrently with metabolic reprogramming. This ensures that activated cells generate the energy substrates necessary to perform their specified function. Likewise, programs among different of immune system vary. By targeting pathways, these differences allow for selective regulation responses. Further, relative susceptibility a inhibitor is dictated by demands; cellular selectivity based on demand. Therefore, where exist in pathways between healthy pathogenic cells, there opportunity agents lacking intrinsic specificity. There are now host studies demonstrating how inhibitors metabolism (e.g., glycolysis, glutamine metabolism, fatty acid oxidation) can regulate responses treat immune-mediated pathogenesis. In this brief review we detail be employed both autoimmunity transplantation.

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