In vitro effects of bethanechol on specimens of intestinal smooth muscle obtained from the duodenum and jejunum of healthy dairy cows.
作者： Julia B. R. Pfeiffer , Meike Mevissen , Adrian Steiner , Christopher J. Portier , Mireille Meylan
关键词:
摘要: Objective—To describe the in vitro effects of bethanechol on contractility smooth muscle preparations from small intestines healthy cows and define muscarinic receptor subtypes involved mediating contraction. Sample Population—Tissue samples duodenum jejunum collected immediately after slaughter 40 cows. Procedures—Cumulative concentration-response curves were determined for agonist with or without prior incubation subtype-specific antagonists an organ bath. Effects influence intestinal location basal tone, maximal amplitude (Amax), area under curve (AUC) evaluated. Results—Bethanechol induced a significant, concentration-dependent increase all variables. The effect was more pronounced jejunal than duodenal circular longitudinal preparations. Significant inhibition bethanecho...
avma.org
core.ac.uk
sci-hub.se 参考文章(63)
A J Roussel, G W Brumbaugh, R C Waldron, A N Baird, Abomasal and duodenal motility in yearling cattle after administration of prokinetic drugs. American Journal of Veterinary Research. ,vol. 55, pp. 111- 115 ,(1994)
Steiner A, Roussel Aj, Martig J, EFFECT OF BETHANECHOL, NEOSTIGMINE, METOCLOPRAMIDE, AND PROPRANOLOL ON MYOELECTRIC ACTIVITY OF THE ILEOCECOCOLIC AREA IN COWS American Journal of Veterinary Research. ,vol. 56, pp. 1081- 1086 ,(1995)
G D Lester, A M Merritt, J Harrison, N C Ringger, T Vetro, L Neuwirth, Effect of bethanechol or erythromycin on gastric emptying in horses. American Journal of Veterinary Research. ,vol. 57, pp. 1771- 1775 ,(1996)
RM Eglen, N Watson, SS Hegde, Muscarinic receptor subtypes and smooth muscle function Pharmacological Reviews. ,vol. 48, pp. 531- 565 ,(1996)
Richard M. Eglen, Muscarinic receptor subtype pharmacology and physiology. Progress in Medicinal Chemistry. ,vol. 43, pp. 105- 136 ,(2005) , 10.1016/S0079-6468(05)43004-0
N J Buckley, S Lazareno, F F Roberts, Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells. Molecular Pharmacology. ,vol. 38, pp. 805- 815 ,(1990)
F J Ehlert, E A Thomas, S A Baker, Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum. Molecular Pharmacology. ,vol. 44, pp. 102- 110 ,(1993)
Minoru Matsui, Daisuke Motomura, Toru Fujikawa, Jian Jiang, Shin-ichi Takahashi, Toshiya Manabe, Makoto M. Taketo, Mice Lacking M2and M3Muscarinic Acetylcholine Receptors Are Devoid of Cholinergic Smooth Muscle Contractions But Still Viable The Journal of Neuroscience. ,vol. 22, pp. 10627- 10632 ,(2002) , 10.1523/JNEUROSCI.22-24-10627.2002
Jesus Gomeza, Peter W. Stengel, Jurgen Wess, Marlene L. Cohen, M2 and M4 Receptor Knockout Mice: Muscarinic Receptor Function in Cardiac and Smooth Muscle In Vitro Journal of Pharmacology and Experimental Therapeutics. ,vol. 292, pp. 877- 885 ,(2000)
M R Brann, G Lambrecht, E Mutschler, J Wess, R Tacke, F Dörje, Antagonist binding profiles of five cloned human muscarinic receptor subtypes. Journal of Pharmacology and Experimental Therapeutics. ,vol. 256, pp. 727- 733 ,(1991)