EFFECT OF BETHANECHOL, NEOSTIGMINE, METOCLOPRAMIDE, AND PROPRANOLOL ON MYOELECTRIC ACTIVITY OF THE ILEOCECOCOLIC AREA IN COWS

摘要: The effect of bethanechol, neostigmine, metoclopramide, and propranolol on myoelectric activity the ileum, cecum, proximal loop ascending colon was determined in 6 healthy Jersey cows implanted with 8 pairs bipolar electrodes. Assigned at random, each cow received 5 treatments 3-day intervals. included bethanechol (0.07 mg/kg body weight, SC), neostigmine (0.02 mg/kg, metoclopramide (0.15 IM), DL-propranolol (0.2 0.9% sodium chloride (NaCl) solution (20 ml, SC). All drugs were administered during early phase I migrating complex ileum. Myoelectric recorded for 4 hours after treatment, data analyzed hour separately. Bethanechol significantly (P < 0.05) increased number cecocolic spikes per minute electrode, duration spike (%), propagated sequences 10 minutes, relative to NaCl, 1 or more recording period. pronounced sequences, whereas mainly (uncoordinated) spikes. Metoclopramide had no significant activity, NaCl. It concluded that and, less likely, dosage used this study may be suitable medical treatment cecal dilatation cattle which hypomotility cecum has reversed. potential advantage vs is worth further evaluation.