Modifiers of gastrointestinal motility of cattle

摘要: Little clinically relevant, evidence-based data about the effect of motility modifiers on GI tract cattle are currently available. Additionally, some published results seem to be contradictory. Three main facts explain this apparent discrepancy: (1) Results may not transferred from one species another, because presence, concentration, location, distribution, and function specific receptors differ significantly among species. (2) The lack a significant smooth muscle preparations in vitro does necessarily exclude certain drug's motility-modifying property affected animals vivo. Certain drugs bind outside myenteric plexus. Others, such as lidocaine adrenergic-, dopaminergic-, opioid-antagonists increase only motility, if inhibitory reflexes or hyperactive state sympathetic nervous system preexists. (3) Effects found healthy experimental vivo similar those spontaneously diseased animals. Accurate reliable will obtained double-blinded, evidence-based, studies Because well-documented extremely rare, intensive research field is warranted future.