Immune modulation by neutrophil subsets

摘要: We show that human neutrophils can suppress T-cell proliferation in acute systemic inflammation and thus have anti-inflammatory functions, next to their well-known pro-inflammatory functions. The suppression is mediated by ROS production integrin MAC-1, which are also important for the mechanisms of neutrophils. Therefore, it realize inhibition neutrophils, or will not necessarily lead inflammation. functions these innate immune cells more complex than was previously expected, adaptive system seem be even entwined appreciated. A better understanding initiating transition from a an neutrophil essential comprehend disease processes