The therapeutic effect of Lipo PGE1 on diabetic neuropathy-changes in endothelin and various angiopathic factors

摘要: A high blood concentration of endothelin (ET)-1 may participate in the onset and progress diabetic microangiopathy, resulting neuropathy. We examined therapeutic effects prostaglandin E1 (PGE1), which possesses both a peripheral vasodilating action inhibition platelet aggregation, on microangiopathy. Increases skin temperature never conduction velocity patients were recorded four weeks after Lipo PGE1 administration. quantitative decrease urinary albumin was also observed, suggesting its efficacy nephropathy. administration reduced elevated circulating plasma ET-1 levels patients. As an increase concentrations is thought to correlate with reduction by be one reason for improvement neuropathy