Midkine and its clinical significance in endometrial carcinoma

摘要: Midkine (MK) is a secreted heparin-binding growth factor. Several types of human cancer have increased MK expression with elevated serum levels. The purpose this study was to determine whether expressed in endometrial carcinoma and evaluate the clinicopathological significance patients carcinoma. Immunohistochemical evaluated 85 samples 33 controls. significantly higher carcinomas than normal endometrium (P < 0.001). Interestingly, highest at margins invasion low superficial areas tumor samples. Using ELISA, we compared concentration 120 46 benign gynecologic tumors. Serum value that diseases = 0.01). Patients positive lymph node metastasis or recurrence, death, had level 0.008, P 0.009, respectively). In conclusion, immunoreactivity endometrium. Additionally, preoperative levels are correlated prognosis presence metastasis. Thus, may be useful biomarker for identifying high risk