Adherent–invasive Escherichia coli blocks interferon‐γ‐induced signal transducer and activator of transcription (STAT)‐1 in human intestinal epithelial cells
作者： Juan C. Ossa , Nathan K. Ho , Eytan Wine , Nelly Leung , Scott D. Gray-Owen
DOI: 10.1111/CMI.12048
关键词:
摘要: Adherent-invasive Escherichia coli (AIEC) is a pathogen isolated from the ileum of patients with Crohn disease. IFNγ key mediator immunity, which regulates inflammatory responses to microbial infections. Previously, we showed enterohemorrhagic E. prevents STAT1 activation. The aim this study was determine whether activation by prevented AIEC infection, and define mechanisms used. Human epithelial cells were infected three different strains or other pathogenic commensal strains. Following stimulated IFNγ, monitored immunoblotting. Our data show that live active protein synthesis machinery able prevent IFNγ-mediated phosphorylation, secreted factor may be involved. We conclude suppression cell signal transduction disease represents novel mechanism evades host immune infection.
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