EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells.
作者： Peter Andersen , Mikkel Wandahl Pedersen , Anders Woetmann , Mette Villingshøj , Marie-Thérése Stockhausen
DOI: 10.1002/IJC.23109
关键词:
摘要: … -activated EGFR induce expression of IRF-1 via phosphorylation of STAT1 and STAT3. In contrast, cells expressing the constitutively active … of inducing IRF-1. We also demonstrate that …
elsevier.com
radiationbiology.dk 
researchgate.net 参考文章(40)
S Harroch, M Revel, J Chebath, Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes. Journal of Biological Chemistry. ,vol. 269, pp. 26191- 26195 ,(1994) , 10.1016/S0021-9258(18)47177-3
M J Van de Vijver, R Kumar, J Mendelsohn, Ligand-induced activation of A431 cell epidermal growth factor receptors occurs primarily by an autocrine pathway that acts upon receptors on the surface rather than intracellularly. Journal of Biological Chemistry. ,vol. 266, pp. 7503- 7508 ,(1991) , 10.1016/S0021-9258(20)89475-7
N Tanaka, T Kawakami, T Taniguchi, Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Molecular and Cellular Biology. ,vol. 13, pp. 4531- 4538 ,(1993) , 10.1128/MCB.13.8.4531
M.W. Pedersen, M. Meltorn, L. Damstrup, H.S. Poulsen, The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy Annals of Oncology. ,vol. 12, pp. 745- 760 ,(2001) , 10.1023/A:1011177318162
Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman, Bryan R.G. Williams, Activation of the interferon system by short-interfering RNAs Nature Cell Biology. ,vol. 5, pp. 834- 839 ,(2003) , 10.1038/NCB1038
C. C. Carter, V. Y. Gorbacheva, D. J. Vestal, Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain. Archives of Virology. ,vol. 150, pp. 1213- 1220 ,(2005) , 10.1007/S00705-004-0489-2
Jo Thompson-Hehir, Michael P. A. Davies, John A. Green, Nigel Halliwell, Kathryn A. Joyce, Jean Salisbury, D. Ross Sibson, Ignace Vergote, Carol Walker, Novel polymerase chain reaction approach for full-coding p53 mutation detection in microdissected archival tumors. Diagnostic Molecular Pathology. ,vol. 9, pp. 110- 119 ,(2000) , 10.1097/00019606-200006000-00007
Hisashi Harada, Keith Willison, Jun Sakakibara, Masaaki Miyamoto, Takashi Fujita, Tadatsugu Taniguchi, Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated Cell. ,vol. 63, pp. 303- 312 ,(1990) , 10.1016/0092-8674(90)90163-9
Alan J Bridge, Stephanie Pebernard, Annick Ducraux, Anne-Laure Nicoulaz, Richard Iggo, Induction of an interferon response by RNAi vectors in mammalian cells Nature Genetics. ,vol. 34, pp. 263- 264 ,(2003) , 10.1038/NG1173
Alexandra Giatromanolaki, Michael I Koukourakis, Konstantinos Ritis, Konstantinos Mimidis, Efthimios Sivridis, Interferon regulatory factor-1 (IRF-1) suppression and derepression during endometrial tumorigenesis and cancer progression. Cytokine. ,vol. 26, pp. 164- 168 ,(2004) , 10.1016/J.CYTO.2004.03.001