Clinical Applications of BCR-ABL Molecular Testing in Acute Leukemia

摘要: Recent advances in molecular genetics impact the health care and outcome of patients with acute lymphoblastic leukemia (ALL). BCR-ABL, a common defect adult ALL, is valuable tumor marker whose detection influences prognosis clinical management decisions. Molecular methods such as fluorescence situ hybridization (FISH), reverse-transcriptase polymerase chain reaction (rtPCR), real-time quantitative rtPCR can be used to detect chimeric BCR-ABL gene or its transcripts. These assays improve our ability measure residual disease estimate risk relapse. On horizon are expression profiles that will likely provide additional information beyond what obtainable current laboratory approaches.