Ausweitung des Spenderpools unter Verwendung marginaler Organe

作者: J. Pratschke , J. Mittler , P. Neuhaus

DOI: 10.1007/S00104-007-1458-6

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摘要: In der Lebertransplantation spielt angesichts grosen Knappheit an Spenderorganen die Verwendung marginaler Organe eine wichtige Rolle. Der Begriff „marginale Spender“ (im angloamerikanischen Sprachraum „extended criteria donor“) ist bisher nicht eindeutig definiert. Die haufigsten Marginalitatskriterien sind hohes Spenderalter, Verfettung Spenderleber und langer intensivstationarer Aufenthalt des Spenders. Einfluss auf Ergebnisse nach kann noch abschliesend beurteilt werden. Einer moglicherweise hoheren Rate Transplantatversagen schlechterem Transplantat- Empfangeruberleben durch Nutzung steht nachweisliche Senkung Sterblichkeit Warteliste gegenuber. Daruber hinaus muss Bedeutung besonderer Risikokonstellationen wie ein hoher MELD-Score („model for endstage liver disease“) oder Hepatitis-C-assoziierte Lebererkrankung Empfangers weiter untersucht

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