Routine storage of red blood cell (RBC) units in additive solution‐3: a comprehensive investigation of the RBC metabolome
作者： Angelo D'alessandro , Travis Nemkov , Marguerite Kelher , F Bernadette West , Rani K Schwindt
DOI: 10.1111/TRF.12975
关键词:
摘要: Background In most countries, packed red blood cells (RBCs) can be stored up to 42 days before transfusion. However, observational studies have suggested that storage duration might associated with increased morbidity and mortality. While clinical trials are underway, impaired metabolism has been documented in RBCs several additive solutions. Here we hypothesize that, despite reported beneficial effects, solution-3 (AS-3) results metabolic impairment weeks the end of unit shelf-life.
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