Invasive streptococcal (group A) infection of soft tissues in a Moscow surgical hospital

摘要: Aim . To study features and risk factors  of soft tissue's invasive streptococcal infection in surgical unit's patients: a) emm-types the most often recovered streptococcus; b) human immune response for antigens (streptolysin-O group A carbohydrate antigen); c) main patient's conditions that complicate course infection. Patients methods 101 patients with infection, which (GAS) nature, were examined. Emm-types determined by comparison emm gene sequenced part data CDC Streptococcus Laboratory. ASO specific anti-group-carbohydrate IgM measured photometry ELISA accordingly.  Patient’s personal analyzed standard statistical pro grams. Results Among 34 all isolates emm28 emm64 registered only infection.  1, 49, 60, 66, 77, 84, 88 often. 23 sera from GAS-infection's patients, 15 (65%) ASO-negative, 6 (26%) ASO-low-positive, 2 (8%) positive, but negative anti-group-A-carbohydrate IgM. Conclusion Lower levels humoral as well factors such trauma, alcoholism, diabetes, chronic venous insufficiency contributed to development severe forms GAS-infection. The GAS one Moscow 2008-2011 registered.