The endocrine role in mammalian sexual differentiation.

作者: JEAN D. WILSON , FREDERICK W. GEORGE , MARILYN B. RENFREE

DOI: 10.1016/B978-0-12-571150-0.50021-4

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摘要: Publisher Summary The hormones play an essential role, in all species, the development and function of ovaries testes, but most species with Y-determined sexual differentiation, administration androgens or estrogens does not cause sex reversal. This chapter explains mechanism by which genetic is ultimately translated into phenotypic because mechanisms are different two types mammals. In marsupial, chromosomal directly dictates major aspects phenotype. There some evidence that factors may control at least one sexually dimorphic trait eutherian mammal: more Y-linked traits appear to influence height tooth size independent endocrine function. human Y chromosome has been mapped YAC cloning, specific gene(s) responsible for these growth phenomena identified. phenotypes form man marsupial be totally dissimilar. both, components controlled testicular there a direct component, difference being contribution male phenotype less important mammal.

参考文章(32)
M Kari, L Alvesalo, R H Osborne, The 47,XYY male, Y chromosome, and tooth size. American Journal of Human Genetics. ,vol. 27, pp. 53- 61 ,(1975)
M B Renfree, L M Watts, A L Griffiths, J M Hutson, G Shaw, The tammar wallaby (Macropus eugenii) and the Sprague-Dawley rat: comparative anatomy and physiology of inguinoscrotal testicular descent. Journal of Anatomy. ,vol. 183, pp. 441- 450 ,(1993)
M Kari, L Alvesalo, Sizes of deciduous teeth in 47,XYY males. American Journal of Human Genetics. ,vol. 29, pp. 486- 489 ,(1977)
S Foote, D Vollrath, A Hilton, D. Page, The human Y chromosome: overlapping DNA clones spanning the euchromatic region Science. ,vol. 258, pp. 60- 66 ,(1992) , 10.1126/SCIENCE.1359640
Nathalie Josso, Laurence Boussin, Bertrand Knebelmann, Claire Nihoul-Fékété, Jean-Yves Picard, Anti-Müllerian hormone and intersex states. Trends in Endocrinology and Metabolism. ,vol. 2, pp. 227- 233 ,(1991) , 10.1016/1043-2760(91)90029-M
Sex determination in marsupials: evidence for a marsupial-eutherian dichotomy Philosophical Transactions of the Royal Society B. ,vol. 322, pp. 41- 53 ,(1988) , 10.1098/RSTB.1988.0112
G Shaw, MB Renfree, RV Short, Primary Genetic-Control of Sexual-Differentiation in Marsupials Australian Journal of Zoology. ,vol. 37, pp. 443- 450 ,(1989) , 10.1071/ZO9890443
GB Sharman, RL Hughes, DW Cooper, The Chromosomal Basis of Sex Differentiation in Marsupials Australian Journal of Zoology. ,vol. 37, pp. 451- 466 ,(1989) , 10.1071/ZO9890451
D Vollrath, S Foote, A Hilton, L. Brown, P Beer-Romero, J. Bogan, D. Page, The human Y chromosome: a 43-interval map based on naturally occurring deletions. Science. ,vol. 258, pp. 52- 59 ,(1992) , 10.1126/SCIENCE.1439769
Andrew H. Sinclair, Philippe Berta, Mark S. Palmer, J. Ross Hawkins, Beatrice L. Griffiths, Matthijs J. Smith, Jamie W. Foster, Anna-Maria Frischauf, Robin Lovell-Badge, Peter N. Goodfellow, A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif Nature. ,vol. 346, pp. 240- 244 ,(1990) , 10.1038/346240A0