Steroid receptor knockout models: phenotypes and responses illustrate interactions between receptor signaling pathways in vivo.
作者： Sylvia Hewitt Curtis , Kenneth S. Korach
DOI: 10.1016/S1054-3589(08)60117-9
关键词:
摘要: Publisher Summary Gonadal steroids have numerous sex- and tissue-specific effects on development reproduction. In the physiological context, nuclear receptor-mediated signaling pathways interact with each other as well pathways. The complexity of this cross-talk is difficult to dissect in vivo or reproduce vitro; transgenic mouse has provided useful models that facilitate study steroid receptor mechanisms interactions. This chapter discusses some interactions, between pathways, how these interactions been clarified, using knockout models. engineering progesterone (PR) (PRKO) estrogen (ER)α (ERKO) mice allowed dissection roles reproduction development. Transgenic are powerful tools enable complex a setting. Some tissues processes altered such way results complicated interpret, case decidualization ERKO. processes, for example, phenotype ERKO ovary, via peripheral ablation, gonadotropin levels. Importantly, unmasked, testosterone-dependent uterotropic effects.
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