Inhibition of volume regulation and efflux of osmoregulatory amino acids by blockers of Cl− transport in cultured astrocytes
作者： Roberto Sánchez-Olea , Claudia Peña , Julio Morán , Herminia Pasantes-Morales
DOI: 10.1016/0304-3940(93)90458-W
关键词:
摘要: Regulatory volume decrease (RVD) in astrocytes was inhibited by the Cl- exchanger blockers 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), dipyridamole and niflumic but not channel inhibitors diphenylamine-2-carboxylate (DPC) anthracene-9-carboxylate (9-AC). The activated efflux of [3H]taurine [3H]D-aspartate (as marker for glutamate) similarly affected these compounds. However, neither RVD nor osmolyte fluxes were significantly reduced removal external Cl-, suggesting that an anion activity is required regulatory process. Alternatively, results suggest molecule may function as unidirectional possibly permeable also to amino acids.
elsevier.com
sci-hub.se 参考文章(23)
L Nowak, P Ascher, Y Berwald-Netter, Ionic channels in mouse astrocytes in culture. The Journal of Neuroscience. ,vol. 7, pp. 101- 109 ,(1987) , 10.1523/JNEUROSCI.07-01-00101.1987
HK Kimelberg, SK Goderie, S Higman, S Pang, RA Waniewski, Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures The Journal of Neuroscience. ,vol. 10, pp. 1583- 1591 ,(1990) , 10.1523/JNEUROSCI.10-05-01583.1990
Yoshihide Imazu, Kiyofumi Kobayashi, Toshikiyo Shohmori, Comparative study of sulpiride and haloperidol on dopamine turnover in the rat brain. Neurochemical Research. ,vol. 14, pp. 459- 464 ,(1989) , 10.1007/BF00964861
M. M. Kay, J. Hughes, I. Zagon, F. B. Lin, Brain membrane protein band 3 performs the same functions as erythrocyte band 3 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 2778- 2782 ,(1991) , 10.1073/PNAS.88.7.2778
Joseph J Falke, Sunney I. Chan, Molecular mechanisms of band 3 inhibitors. 2. Channel blockers. Biochemistry. ,vol. 25, pp. 7895- 7898 ,(1986) , 10.1021/BI00372A016
Fabio Franciolini, Anna Petris, Chloride channels of biological membranes Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes. ,vol. 1031, pp. 247- 259 ,(1990) , 10.1016/0304-4157(90)90009-2
Joseph J. Falke, Sunney I. Chan, Molecular mechanisms of band 3 inhibitors. 3. Translocation inhibitors. Biochemistry. ,vol. 25, pp. 7899- 7906 ,(1986) , 10.1021/BI00372A017
Sigrid Lepke, Anja Becker, Hermann Pascow, Mediation of inorganic anion transport by the hydrophobic domain of mouse erythroid band 3 protein expressed in oocytes of Xenopus laevis. Biochimica et Biophysica Acta. ,vol. 1106, pp. 13- 16 ,(1992) , 10.1016/0005-2736(92)90215-8
G.T.A. McEwan, C.D.A. Brown, B.H. Hirst, N.L. Simmons, Hypo-osmolar stimulation of transepithelial Cl- secretion in cultured human T84 intestinal epithelial layers. Biochimica et Biophysica Acta. ,vol. 1135, pp. 180- 183 ,(1992) , 10.1016/0167-4889(92)90135-X
A voltage-gated chloride conductance in rat cultured astrocytes Proceedings of The Royal Society B: Biological Sciences. ,vol. 228, pp. 267- 288 ,(1986) , 10.1098/RSPB.1986.0055