The role of α2,3-linked sialylation on clear cell type epithelial ovarian cancer
作者： Pi-Lin Sung , Kuo-Chang Wen , Huann-Cheng Horng , Chia-Ming Chang , Yi-Jen Chen
DOI: 10.1016/J.TJOG.2018.02.015
关键词:
摘要: Abstract Objective Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous epithelial ovarian cancer (EOC). The aim the current further attempts to evaluate altered α 2,3-sialylation on behavior clear cell EOC (C-EOC). Materials and methods Immunohistochemistry staining, bioinformatics analysis tissue array were used disclose clinical significance over α2,3-sialylation in C-EOC. An α2,3 sialylation inhibitor, soyasaponin (SsaI) investigate change C-EOC line. Results We reconfirmed α2,3-sialylation, instead α2,6- sialylation, late-stage Soyasaponin could inhibit lines increase E-cadherin subsequently suppressing migration cells. Conclusions demonstrated important role α2,3-linked targeting might offer as a potential therapeutic strategy future.
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