Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer

摘要: Sialyltransferases transfer sialic acid to nascent oligosaccharides and are upregulated in cancer. The inhibition of sialyltransferases is emerging as a potential strategy prevent metastasis several cancers, including ovarian ST3GAL1 sialyltransferase that catalyzes the from cytidine monophosphate-sialic galactose-containing substrates associated with cancer progression chemoresistance. However, function uncertain. Herein, we use qRT-PCR, western blotting, immunohistochemistry assess expression tissue cell lines investigate whether it influences resistance paclitaxel vitro mouse xenograft model. We found tissues SKOV-3 OVCAR3 but downregulated A2780 cells. Overexpression cells increases growth, migration, invasion whereas knockdown decreases invasion. Furthermore, overexpression while downregulation vitro, tumorigenicity vivo. Transforming growth factor-β1 can increase induce epithelial–mesenchymal transition (EMT). inhibits EMT expression. Taken together, our findings have identified regulatory mechanism involving may be promising target for overcoming carcinoma.