Dynamic PET 18F-FDG Studies in Patients with Primary and Recurrent Soft-Tissue Sarcomas: Impact on Diagnosis and Correlation with Grading
作者： Antonia Dimitrakopoulou-Strauss , Ludwig G. Strauss , Frank Willeke , Thomas Lehnert , Cyrill Burger
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摘要: The purpose of this study was to evaluate 18F-FDG PET studies primary and recurrent sarcomas for diagnosis correlation with grading. Methods: evaluation included 56 patients, 43 histologically proven malignancies 13 benign lesions. Seventeen patients were referred suspicion on a tumor, the remaining 39 tumor. FDG accomplished as dynamic series 60 min. kinetics performed using following parameters: standardized uptake value (SUV), global influx, computation transport constants K1–k4 consideration distribution volume (VB) according two-tissue-compartment model, fractal dimension based box-counting procedure (parameter inhomogeneity tumors). Results: Visual revealed sensitivity 76.2%, specificity 42.9%, an accuracy 67.9%. vascular fraction VB SUV higher in malignant tumors compared lesions (t test, P 80%).
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