作者: Chunda Zhou , Robert Riehn
DOI: 10.1103/PHYSREVE.92.012714
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摘要: Recent studies have shown that double-stranded DNA can collapse in the presence of a strong electric field. Here we provide an in-depth study under weak confinement microchannels as function buffer strength, driving frequency, applied electric-field and molecule size. We find critical field at which molecules (tens kV/m) is strongly dependent on frequency (100-800 Hz) molecular size (20-160 kbp), weakly ionic strength (8-60 mM). argue apparent stretching very high fields artifact finite frame time video microscopy.