Concentration Polarization in Translocation of DNA through Nanopores and Nanochannels
作者： Siddhartha Das , Pavel Dubsky , Albert van den Berg , J. C. T. Eijkel
DOI: 10.1103/PHYSREVLETT.108.138101
关键词:
摘要: In this Letter we provide a theory to show that high-field electrokinetic translocation of DNA through nanopores or nanochannels causes large transient variations the ionic concentrations in front and at back due concentration polarization (CP). The CP strong local conductivity variations, which can successfully explain nontrivial current transients distributions observed molecular dynamics simulations nanopore translocations as well dips spikes measured for translocating hairpin DNA. Most importantly, future sequencing by will be based on time-varying electrical conductance, CP, must considered experimental design interpretation-currently these studies are mostly incomplete pore conductance models ignore conductance.
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