Fabrication of Organic-Inorganic Hybrid Nanopore and its Application in Biosensing
作者： Lei Liu , Bing Wang , Yue Yang , Zhong Hua Ni , Yun Fei Chen
DOI: 10.4028/WWW.SCIENTIFIC.NET/KEM.562-565.658
关键词:
摘要: Nanopore and nanopore based bio-sensing technology have become into more interesting research area in the past ten years. In this work, micro-pore Si-S3N4 chips was fabricated characterized by Focused Ion Beam (dual Beam), then S3N4 pore covered Polycarbonate (PC) membrane containing 50nm nanopores sealed using polydimethylsiloxane (PDMS) to get hybrid micro-nanopores. The obtained chip with together two liquid cells integrated an ionic current detection device for biosensing. Based on device, λ-DNA electrolytic solution can be detected when it is electrophoretically driven through nanopores, different gestures of translocation also discriminated.
sci-hub.se 参考文章(27)
Hagan Bayley, Paul S. Cremer, Stochastic sensors inspired by biology Nature. ,vol. 413, pp. 226- 230 ,(2001) , 10.1038/35093038
P S Spinney, D G Howitt, R L Smith, S D Collins, Nanopore formation by low-energy focused electron beam machining. Nanotechnology. ,vol. 21, pp. 375301- ,(2010) , 10.1088/0957-4484/21/37/375301
Qing Zhao, Yang Wang, Jianjin Dong, Lina Zhao, XF Rui, Dapeng Yu, None, Nanopore-based DNA analysis via graphene electrodes Journal of Nanomaterials. ,vol. 2012, pp. 4- ,(2012) , 10.1155/2012/318950
Qian Jin, Aaron M. Fleming, Cynthia J. Burrows, Henry S. White, Unzipping Kinetics of Duplex DNA Containing Oxidized Lesions in an α-Hemolysin Nanopore Journal of the American Chemical Society. ,vol. 134, pp. 11006- 11011 ,(2012) , 10.1021/JA304169N
Siddhartha Das, Pavel Dubsky, Albert van den Berg, J. C. T. Eijkel, Concentration Polarization in Translocation of DNA through Nanopores and Nanochannels Physical Review Letters. ,vol. 108, pp. 138101- 138101 ,(2012) , 10.1103/PHYSREVLETT.108.138101
D. Dobrev, J. Vetter, R. Neumann, N. Angert, Conical etching and electrochemical metal replication of heavy-ion tracks in polymer foils Journal of Vacuum Science & Technology B. ,vol. 19, pp. 1385- 1387 ,(2001) , 10.1116/1.1381066
Abraham Mara, Zuzanna Siwy, Christina Trautmann, Jackson Wan, Fredrik Kamme, An Asymmetric Polymer Nanopore for Single Molecule Detection Nano Letters. ,vol. 4, pp. 497- 501 ,(2004) , 10.1021/NL035141O
Ranulu S. S. de Zoysa, D. M. Milan Krishantha, Qitao Zhao, Jyoti Gupta, Xiyun Guan, Translocation of single-stranded DNA through the α-hemolysin protein nanopore in acidic solutions. Electrophoresis. ,vol. 32, pp. 3034- 3041 ,(2011) , 10.1002/ELPS.201100216
Meni Wanunu, Swati Bhattacharya, Yun Xie, Yitzhak Tor, Aleksei Aksimentiev, Marija Drndic, Nanopore Analysis of Individual RNA/Antibiotic Complexes ACS Nano. ,vol. 5, pp. 9345- 9353 ,(2011) , 10.1021/NN203764J
C. Chad Harrell, Youngseon Choi, Lloyd P. Horne, Lane A. Baker, Zuzanna S. Siwy, Charles R. Martin, Resistive-Pulse DNA Detection with a Conical Nanopore Sensor† Langmuir. ,vol. 22, pp. 10837- 10843 ,(2006) , 10.1021/LA061234K