Fever of unknown origin: prospective comparison of [18F]FDG imaging with a double-head coincidence camera and gallium-67 citrate SPET.

摘要: Gallium-67 citrate is currently considered as the tracer of first choice in diagnostic workup fever unknown origin (FUO). Fluorine-18 2'-deoxy-2-fluoro-D-glucose (FDG) has been shown to accumulate malignant tumours but also inflammatory processes. The aim this study was prospectively evaluate FDG imaging with a double-head coincidence camera (DHCC) patients FUO comparison planar and single-photon emission tomography (SPET) 67Ga scanning. Twenty underwent DHCC which included transaxial longitudinal whole-body tomography. In 18 these subjects, SPET performed. images were interpreted by two investigators, both blinded results other modalities. Forty percent (8/20) had infection, 25% (5/20) auto-immune diseases, 10% (2/20) neoplasms 15% (3/20) diseases. Fever remained unexplained patients. Of 20 studied, positive essentially contributed final diagnosis 11 (55%). sensitivity detecting focus 84% specificity, 86%. Positive negative predictive values 92% 75%, respectively. If analysis restricted who investigated FDG, 81% 90% accuracy (again aforementioned patients) lower (sensitivity, 36%; 86%; values, 80% 46%, respectively). yielded 67% specificity 78%. 75% 70%, A low (45%), combined high (100%), found imaging. 100% 54%, It concluded that context FUO, performed superior SPET. This seems be consequence kinetics compared those better spatial resolution system either dedicated PET or should procedure choice.