Macrophages and Myeloid Dendritic Cells, but Not Plasmacytoid Dendritic Cells, Produce IL-10 in Response to MyD88- and TRIF-Dependent TLR Signals, and TLR-Independent Signals
作者： André Boonstra , Ricardo Rajsbaum , Mary Holman , Rute Marques , Carine Asselin-Paturel
DOI: 10.4049/JIMMUNOL.177.11.7551
关键词:
摘要: We have previously reported that mouse plasmacytoid dendritic cells (DC) produce high levels of IL-12p70, whereas bone marrow-derived myeloid DC and splenic substantially lower this cytokine when activated with the TLR-9 ligand CpG. now show in response to CpG stimulation, IL-10 are secreted by macrophages, intermediate DC, but no detectable is DC. MyD88-dependent TLR signals (TLR4, 7, 9 ligation), Toll/IL-1 receptor domain-containing adaptor-dependent (TLR3, 4 ligation) as well non-TLR (CD40 induced macrophages addition proinflammatory cytokines. IL-12p70 expression was suppressed endogenous an even greater extent CD8alpha(-) CD8alpha(+) Although did not upon exogenously their production IL-12, TNF, IFN-alpha, showing trans autocrine regulation these cytokines
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