Biventricular myocardial strain analysis in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) using cardiovascular magnetic resonance feature tracking

摘要: Fibrofatty degeneration of myocardium in ARVC is associated with wall motion abnormalities. The aim this study was to examine whether Cardiovascular Magnetic Resonance (CMR) based strain analysis using feature tracking (FT) can serve as a quantifiable measure confirm global and regional ventricular dysfunction patients support the early detection ARVC. We enrolled 20 ARVC, 30 borderline 22 subjects positive family history but no clinical signs manifest 10 healthy volunteers (HV) served controls. 15 received genotyping for Plakophilin-2 mutation (PKP-2), which 7 were found be positive. Cine MR datasets all assessed myocardial FT (TomTec Diogenes Software). Global rate radial, circumferential longitudinal mode right left ventricle. In addition at segmental level performed free wall. RV rates (−0.68 ± 0.36 sec−1) (−0.85 significantly reduced comparison HV (−1.38 0.52 sec−1, p ≤ 0.05). Furthermore, basal compared (strain: –5.1 2.7 vs. -9.2 3.6%; rate: –0.31 0.13 sec–1 -0.61 0.21 sec–1). Even or normal ejection fraction (n=30) proved (–0.9 0.3 -1.4 0.5 sec–1; < 0.005). PKP-2 there clear trend towards more pronounced impairment rate. On ROC best discriminators between (AUC: 0.9 0.92, respectively). CMR an objective useful quantification abnormalities It allows differentiation HV, even if still normal.