Design, synthesis and biological evaluation of azithromycin glycosyl derivatives as potential antibacterial agents.
作者： Lei Zhang , Xiaoyun Chai , Baogang Wang , Shichong Yu , Honggang Hu
DOI: 10.1016/J.BMCL.2013.07.042
关键词:
摘要: A series of 11,12-cyclic carbonate azithromycin-4″-O-carbamoyl glycosyl derivatives were designed, synthesized, and evaluated as antibacterial agents to search for target compounds with excellent activity. The results preliminary tests against eight strains in vitro revealed that all the title exhibited improved activities broad spectrum compared parent compound. glycosylated side chains may be pharmacophores responsible
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